His trip comes as wars continue to unsettle Europe and rapid advances in artificial intelligence challenge long-held ideas about human identity and responsibility.
The pope is expected to use meetings, public addresses and religious ceremonies to renew his calls for diplomacy and an end to armed conflict.
His message will also focus on the need for moral reflection as artificial intelligence transforms work, communication and decision-making.
The visit gives Leo an opportunity to engage French political and religious leaders while addressing a broader international audience.
The trip unfolds amid mounting pressure on global institutions to respond to humanitarian crises, technological change and growing social divisions.
By linking peace efforts with questions about the future of humanity, the pope is seeking to frame the Church’s role in two defining debates of the modern era.