The incident occurred Wednesday, prompting authorities to examine the circumstances surrounding the disruption and the actions of those involved.
The flight was operated by Dubai-based carrier Flydubai and was traveling toward Israel when the reported altercation took place.
UAE officials have not disclosed the identities of the people involved, the nature of the confrontation or whether anyone was injured.
Investigators are expected to review cockpit procedures, passenger and crew accounts, and any available security footage as they determine whether the incident was a criminal disturbance or had broader security implications.
The inquiry comes amid heightened regional tensions and increased scrutiny of flights operating between the Gulf and Israel.
No official finding has been announced, and authorities have not said whether arrests or charges have been made. Further details are expected as the investigation proceeds.